変異株流行期ごとのlong COVID。
— Sukuna (@SukunaBikona7) July 18, 2024
COVID-19感染後1年間のlong COVIDはワクチン未接種者で100人あたりデルタ前10.42件、デルタ流行期9.51件、オミクロン7.76件、接種者で100人あたりデルタ流行期5.34件、オミクロン3.50件。
→ https://t.co/fS5leiBnp0
オミクロンではそれ以前と比べ、消化器系と内分泌系のlong COVIDリスクが増した。https://t.co/EwXMO2u6yl
— Sukuna (@SukunaBikona7) July 18, 2024
📣 Our new paper in @NEJM
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Has the risk of #LongCovid changed over the course of the pandemic?
By @Biostayan, Taeyoung Choi and me
A 🧵https://t.co/wN9oePBkRg
We enrolled people who had SARS-CoV-2 infection in the pre-delta, delta and omicron eras (441,583 people) and built 3 era-specific controls
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
We assessed the cumulative incidence of #LongCovid at 1 year after infection by pandemic era & vaccination statushttps://t.co/wN9oePAN1I pic.twitter.com/vAW0kmDBRO
Among unvaccinated people, the cumulative incidence of #LongCovid declined over the course of the pandemic from a high of 10.4 per 100 adults infected in the pre-delta era to 7.7 per 100 adults infected in the omicron erahttps://t.co/wN9oePBkRg pic.twitter.com/cKeVJpFGmG
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Among vaccinated people, the cumulative incidence of #LongCovid declined from 5.3 per 100 adults infected in the delta era to 3.5 per 100 adults infected in the omicron erahttps://t.co/wN9oePBkRg pic.twitter.com/Gv1KMOti6z
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Overall, the cumulative incidence of #LongCovid declined from a high of 10.4 per 100 unvaccinated persons infected in the pre-delta era to 3.5 per 100 vaccinated persons infected in the omicron erahttps://t.co/wN9oePBkRg pic.twitter.com/Wx0EWvNDND
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Much of the decline (~ 70%) was attributable to vaccination and about 30% was attributable to era effects (i.e. changes in characteristics of the virus and other temporal factors)#LongCovid https://t.co/wN9oePBkRg pic.twitter.com/ZbQB52CjWP
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
We noted a shift in the features of #LongCovid with increased risk of GI and metabolic disorders in omicron – these went up (not down) in omicron compared to prior eras
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Each variant has its own Long Covid fingerprint.https://t.co/wN9oePBkRg pic.twitter.com/J0jVLqaTx0
The remaining risk of 3.5% among vaccinated people infected in the omicron era is substantial
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
This will contribute millions of additional Long Covid cases - adding to an exorbitant toll of chronic disease & disabilityhttps://t.co/wN9oePBkRg pic.twitter.com/zO1KlZ0UOL
Terrific editorial by Cliff Rosen @Rosen_Lab https://t.co/wN9oePBkRghttps://t.co/pqEN40v4ME
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024
Thanks to the amazing @sourwine for developing this press release.@WUSTLnews@WUSTLmed@WUSTLhttps://t.co/Le6xMMubC4
— Ziyad Al-Aly, MD (@zalaly) July 17, 2024