関西医大から京都府立医大への道 【6】

 

【6】関西医大から京都府立医大への道

Retraction Watch / 2011.07.02 00:02 / 推薦数 : 4

【3】関西医大から京都府立医大への道　では同じ研究グループからの2つの論文を読みくらべましたが、

今回の2つの論文は別々の施設からの発表です。

先発論文は1998年イスラエルのグループからの発表。

対する後発論文は2000年おなじみ関西医大のグループです。 

 

関西医大　The delayed response of JNK suggested that JNK is involved in a later stage of transcription regulation and suggests that the signaling machinery involved in the activation of JNK is different from that leading to ERK activation.  Our results suggested that Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC.  The signal is then transmitted to the Pyk2 and further to the small G protein Rac1 but not Cdc42, although the direct activation of Rac1 by Pyk2 is not proved in this study.

イスラエル　The delayed response of JNK observed here (Fig. 1) may indicate that JNK is involved in a later stage of transcription regulation and suggests that the signaling machinery that is involved in the activation of JNK is different from that leading to ERK activation.  This upstream machinery was elucidated in this study, and our results suggest that GnRH binding to its receptors triggers the activation ofPKC, which occurs most probably via the heterotrimeric Gq protein and PLC.  The signal is then transmitted to a Src-family PTK and further to the sGPs CDC42 and possibly Rac1.

関西医大　Although in many cases Rac1 and Cdc42 use similar guanine nucleotide exchange factors, the effect of Cdc42 on Ang II-JNK pathway seems to be limited.  Similar phenomena were reported for serum-induced proliferation and JNK activation by gonadotropin-released hormone.  Thus, the activation of JNK by Ang II in cardiac fibroblasts involves Ras-independent activation of Rac1 by Pyk2.

イスラエル　Although in many cases CDC42 and Rac1 seem to use similar guanine nucleotide exchange factors, the effect of Rac1 on the GnRH-JNK pathway seems to be limited.  Similar phenomenon, where CDC42 transmits downstream signals without the involvement of Rac1, was recently reported for serum-induced proliferation.  Ha-Ras does not seem to be significantly involved in GnRH-induced signaling that contributes to the JNK cascade.

関西医大　The ERK cascade is not the only route by which Ang II communicates with the nucleus.  Here, the JNK pathway was shown to be activated in response to Ang II, to a much greater extent than the ERK cascade.

イスラエル　However, the ERK cascade is not the only route by which GnRH communicates with the nucleus.  Here the JNK pathway is shown to be significantly activated in response to GnRH-a, to a much greater extent than the ERK cascade.

 

かなり専門的な同じ分野のことを書くと、これぐらいよく似たものに自然になっちゃう、こともあり得ます？

【7】関西医大から京都府立医大への道 へ続きます。