New Coronavirus Infection Treatment Method] ver.4
Hello everyone. The following post was described on February 14. I have just little knowledge about available medicines of protease inhibitors, but today I am aware that a serine protease inhibitor that inhibits autolysis of pancreatitis is being used in clinical practice. It was already there. The University of Tokyo have announced that the drug "Nafamostat" is effective against the new coronavirus. I believe that pneumonia will not worsen if "granzyme" from cytotoxic T-cells, which is released and activated through cytokine storm, can be suppressed.
I previously suggested here that the steroid therapies, and recently it has been tested as inhalant type; this evidence was introduced in the media. With the steroid inhalant, the local concentration of ot can be higher, and it does not affect to whole body. When administered systemically, it can be aggravated because it suppresses the entire immune system. The inhalants would be one of a good option. Other serine protease inhibitors might also be effective. Let's save lifes!
The following are some of the February 14 recommendations. The effect of the protease inhibitor was predicted at that time. I didn't take a new medicine that already exists.
[Partially omitted]
When cytotoxic T-cells attack target cells such as cancer cells, they also use hydrogen peroxide (H2O2), superoxide anion (02-), and nitric oxide (NO). Perforin and "granzyme" and these will destroy cells. I think that pneumonia caused by new coronavirus may be caused by these abnormal activities. I don't have enough information if we already have the enzyme inhibiters in clinical use. Please give me a comment if you have a good way to inhibit extracellular serine proteases.
We will continue to propose new types of coronavirus infectious disease treatment.
Bye Bye
by ebisen
