【論】Giordano,2001,Organ-specific molecular classif～

Thomas J.Giordano, Kerby A.Shedden, Donald R.Schwartz, Rork Kuick, Jeremy M.G.Taylor, Nana Lee, David E.Misek, Joel K.Greenson, Sharon L.R.Kardia||, David G.Beer, Gad Rennert, Kathleen R.Cho, Stephen B.Gruber, Eric R.Fearon and Samir Hanash
Organ-Specific Molecular Classification of Primary Lung, Colon, and Ovarian Adenocarcinomas Using Gene Expression Profiles
American Journal of Pathology. 2001;159:1231-1238.
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・単一の組織ではなく複数種類の組織（肺、腸、子宮）の癌のマイクロアレイデータを解析し、各組織に対して特有に発現する遺伝子を抽出する。
・データ：57 lung, 51 colon and 46 ovary adenocarcinomas, 7129 genes
・解析法：PCA ("five-nearest neighbors with majority voting") and cross-validated prediction
・結果：各組織に対して、上位20個の遺伝子をリストアップ

・意義「The establishment of organ-specific gene expression patterns represents a crucial first step in the clinical application of the molecular approach.」
・概要「In this study, we compared the gene expression profiles of 154 primary adenocarcinomas of lung, colon, and ovary and demonstrated these profiles could discriminate the tumors in an organ-specific manner. In addition, we identified genes that are potentially useful as diagnostic markers for these tumors.」